Citations. Asymmetric graves ophthalmopathy as a sole manifestation of autoimmune hypothyroidism. In the same study asymmetry was more prevalent in females and measurements from the right orbit were greater than the left (16). Read the latest articles of Trends in Endocrinology & Metabolism at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature Jang SY, Lee SY, Lee EJ, Yoon JS. doi: 10.1046/j.1365-2265.1997.2331047.x, 28. There is no contraindication in regards to any treatment modality including antithyroid drugs, radioactive iodine, and/or total thyroidectomy for mild asymmetric and/or unilateral GO, while in moderate to severe cases radioiodine should be avoided, similarly to bilateral symmetric disease (42). doi: 10.1089/thy.2015.0031, 27. GO is closely associated with thyroid autoimmunity, and although it is classically linked with hyperthyroidism, GO features have been described in hypothyroid or euthyroid individuals (4). Is sleeping position related to asymmetry in bilateral Graves’ ophthalmopathy? Perros P, Crombie AL, Matthews JN, Kendall-Taylor P. Age and gender influence the severity of thyroid-associated ophthalmopathy: a study of 101 patients attending a combined thyroid-eye clinic. doi: 10.1530/EJE-07-0450, 43. Therefore, more studies are needed to study asymmetric GO and shed light on the mechanisms leading to asymmetry. doi: 10.1097/MAJ.0b013e3182582330, 40. Furthermore, previous studies have shown associations of asymmetric/unilateral GO with disease activity and severity and it is crucial that large cohorts include patients of different clinical status. Perros P, Zarkovic MP, Panagiotou GC, Azzolini C, Ayvaz G, Baldeschi L, et al. Clin Endocrinol (2005) 63:395–402. Verma SK, Jain N, Saraf S, Singh SK. Eur J Endocrinol (2018) 178:635–43. Teprotumumab for the Treatment of Active Thyroid Eye Disease. Shackelford TK, Larsen RJ. Animal and mechanistic studies are needed to provide more in depth understanding of the mechanisms leading to disease progression and bilaterality and could identify possible novel therapeutic targets at a molecular level. It has been suggested that unilateral GO may progress to bilateral disease (11) and we have also found that asymmetry was associated with more severe and active GO (12). BackgroundCushing’s disease is associated with an increased risk of pulmonary fungal infection, which could be a relative contraindication for pituitary adenoma excision surgery.CaseWe report a case of a patient with Cushing’s disease and pulmonary Cryptococcus neoformans. Eye (2006) 20:569–73. Eur J Internal Med (2008) 19:531–6. It is important that unilateral GO be differentially diagnosed from orbital diseases affecting one eye, such as orbital tumors, such as lymphoma (39, 40). Received: 29 September 2020; Accepted: 16 November 2020;Published: 17 December 2020. Clin Endocrinol (2020). With an Impact Factor of 3.675, Frontiers in Endocrinology is the 2nd most cited open-access journal in Endocrinology & Metabolism. A 48-year-old woman was admitted to our hospital because of moon face and edema. Kahaly GJ, Petrak F, Hardt J, Pitz S, Egle UT. Eur J Endocrinol (2008) 158:69–75. Front. doi: 10.1159/000266782. Multi-center study on the characteristics and treatment strategies of patients with Graves’ orbitopathy: the first European Group on Graves’ Orbitopathy experience. Seiji F, Moreira RS, De Angelis MA, Smith Chairman RL. However, in a recently published retrospective hospital-based report from India, unilateral disease was much higher at 36% and significantly more common among silent presenters compared to the clinically active group (33). Graves’ orbitopathy (GO) is the most common extrathyroidal feature of Graves’ disease (1) with an estimated prevalence of 10/10,000 persons in European populations (2), while more recent data have shown variable prevalence between 25% and over 50% in Graves’ hyperthyroidism cases (3) worldwide. With regards to correlation with older age, we have confirmed previous findings supporting higher prevalence and more severe asymmetry in older and especially men (12, 37), in keeping with previously described associations between age and male gender with severity of GO in patients with bilateral disease (38). Indices of craniofacial asymmetry. Wiersinga W, Zarkovic M, Bartalena L, Donati S, Perros P, Okosieme O, et al. Frontiers in Neuroendocrinology Impact Factor IF 2020|2019|2018 - BioxBio Endocrinology Impact Factor, IF, number of article, detailed information and journal factor. Ophthalmic Res (1989) 21:73–82. Buescu A, Teixeira P, Coelho S, Donangelo I, Vaisman M. Orbital lymphoma misdiagnosed as Graves’ ophthalmopathy. • Psychosocial morbidity of Graves’ orbitopathy. Normal values of hertel exophthalmometry in children, teenagers, and adults from Tehran, Iran. 31. In a study of 127 human skulls (254 orbits) of individuals aged between newborn to 76 years, asymmetry in orbital anatomy (greater horizontal diameter, greater vertical diameter, orbital perimeter and orbital base area) was present in all cases except four, with variability between 2.47 and 4.47% between the right and left orbit (16). Research network for academics to stay up-to-date with the latest scientific publications, events, jobs, video lectures, blogs and news. There is a need for better documentation of the suggestions that asymmetric/unilateral GO might run a milder course or be a prelude to bilateral disease. doi: 10.1097/01.IOP.0000124675.80763.5A, 14. Herein, we review the available literature on asymmetric GO and highlight differences compared with bilateral disease. Other differentials affecting the orbit including other orbital tumors or pseudotumors, carotid cavernous fistulae, and dermoid and/or epidermoid cysts need to be excluded, too. doi: 10.1089/thy.2017.0365, 10. View all N Engl J Med (2010) 362:726–38. have speculated that asymmetric distribution of antigen or inflammatory processes may be the cause of asymmetrical expansion of orbital contents (13), though this was not explored in any studies so far. Read More . The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota. Loop is the open research network that increases the discoverability and impact of researchers and their work. • Only Open Access Journals Only SciELO Journals Only WoS Journals Cloudflare Ray ID: 6044941f696532aa Orphanet J Rare Dis (2017) 12:72. doi: 10.1186/s13023-017-0625-1, 3. Predictive score for the development or progression of Graves’ orbitopathy in patients with newly diagnosed Graves’ hyperthyroidism. Impact Factor 3.644 ... Diabetes is a specialty section of Frontiers in Endocrinology and Frontiers in Public Health. Moura Neto A, Denardi FC, Delamain MT, Tambascia MA, Vassallo J, Caldato R, et al. The presence of GO is associated with increased psychological burden and, in severe cases may cause blindness. 1. Research topics. The present mini-review summarizes important information for both clinicians and researchers and also provides the impetus for further research. Frontiers in Neuroendocrinology Impact Factor, IF, number of article, detailed information and journal factor. Chin YH, Ng CH, Lee MH, Koh JWH, Kiew J, Yang SP, et al. doi: 10.1056/NEJMoa1012985, 44. Exophthalmos of patients with Graves’ disease in Chinese of Taiwan. Eur J Endocrinol (2011) 165:899–905. Thyroid (2017) 27:1475–80. doi: 10.1530/EJE-11-0548, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. Euthyroid and primarily hypothyroid patients develop milder and significantly more asymmetrical Graves ophthalmopathy. BioMed Res Int (2018) 2018:4845894. doi: 10.1155/2018/4845894, 45. The disease most often presents bilaterally and symmetrically with lid retraction, exophthalmos. doi: 10.1111/cen.14296, 4. Therefore, the goal in managing asymmetric or unilateral GO should be: a) to ensure symptoms are alleviated and sight is not threatened, similarly to bilateral GO; b) to take measures that may prevent progression to bilateral symptomatology; c) surgical rehabilitation when indicated. Shorter duration of symptoms (29) and thyroid status might be associated with asymmetry. doi: 10.1038/s41574-019-0305-4, 6. Herein, we review the literature on asymmetric GO and highlight its differences compared with bilateral GO. Front. Kashkouli MB, Kaghazkanani R, Heidari I, Ketabi N, Jam S, Azarnia S, et al. Orbital lymphoma mimicking ophthalmopathy in a patient with Graves’. Such studies may provide further answers in regards to GO development and management. With an Impact Factor of 3.519, Frontiers in Endocrinology is the 4th most-cited open-access journal in its field Journal impact: Frontiers in Pharmacology July 6, 2018 Citation: Wang G, Zou H, Lai C, Huang X, Yao Y and Xiang G (2020) Repression of MicroRNA-124-3p Alleviates High-Fat Diet–Induced Hepatosteatosis by Targeting Pref-1. Indexed in Web of Science, PubMed, MEDLINE, and Scopus. Li Q, Ye H, Ding Y, Chen G, Liu Z, Xu J, et al. N Engl J Med (2011) 364:1920–31. Ye X, Bo X, Hu X, Cui H, Lu B, Shao J, et al. Sheikh M, Abalkhail S, Doi SA, Al-Shoumer KA. Angle Orthodontist (1981) 51:214–26. Loop is the open research network that increases the discoverability and impact of researchers and their work. doi: 10.1111/j.1440-1673.2007.01721.x, 25. Scope. Wiersinga WM, Smit T, van der Gaag R, Mourits M, Koornneef L. Clinical presentation of Graves’ ophthalmopathy. Normal measurement of orbital structures: implications for the assessment of Graves’ ophthalmopathy. Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients. doi: 10.1371/journal.pone.0176064, 37. Expression of lncRNA-HOTAIR in the serum of patients with lymph node metastasis of papillary thyroid carcinoma and its impact. Clin Endocrinol (2017) 86:247–55. Orbit (2009) 28:342–6. IF . 10 Chebib FS, Chamma AM. Journals range from life sciences and health to engineering, robotics and humanities. doi: 10.1056/NEJMra0905750, 5. 2010-2020: Scope: Frontiers in Endocrinology publishes rigorously peer-reviewed research from basic molecular and cellular communication to clinical care, advancing our understanding of the endocrine system, and leading to novel therapies for some of the most prevalent health issues such as obesity, diabetes, reproduction and aging. Perros P, Hegedus L, Bartalena L, Marcocci C, Kahaly GJ, Baldeschi L, et al. Asymmetry of the human face is well documented (14, 15), while asymmetry in the orbital anatomy of normal human skulls has been shown to be the norm. The initial clinical characteristics of Graves’ orbitopathy vary with age and sex. Br J Ophthalmol (2009) 93:1052–6. Current evidence suggests that patient presenting with asymmetric or unilateral GO may progress to bilateral disease, which clinicians treating patients with GO need to be aware of. doi: 10.1136/bcr-2012-007485, 42. Kendler DL, Lippa J, Rootman J. Fox TJ, Anastasopoulou C. Graves Orbitopathy. Smoking cessation advice and restoring the euthyroid state are important pillars in the management of asymmetric GO. In mild cases of asymmetric GO patients may still benefit from selenium supplementation (43). Elasticity of orbital septae or other local factors, associated with unilateral triggers such as infections or difference in potential for adipogenesis have also been suggested (12). J Pers Soc Psychol (1997) 72:456–66. Efficacy of rituximab treatment for thyroid-associated ophthalmopathy as a result of intraorbital B-cell depletion in one patient unresponsive to steroid immunosuppression. Impact Factor 3.644 ... Frontiers in Endocrinology Cancer Endocrinology Toggle navigation Section (current) Section; ... Cuthbertson DJ and Pritchard DM (2020) Frequency and Causes of False-Positive Elevated Plasma Concentrations of Fasting Gut Hormones in a Specialist Neuroendocrine Tumor Center. GO may also cause a psychological and financial burden (8), primarily but not exclusively due to cosmetic concerns, as well as increase the risk for suicide (9), and impairment of quality of life of patients (10). Tsai CC, Kau HC, Kao SC, Hsu WM. Given that the pathophysiological mechanisms causing unilateral or asymmetric GO appear to be similar to the well-described bilateral GO, treatment of asymmetric GO is generally the same with bilateral disease and is usually dependent on disease severity. Der Journal Impact 2019 von Frontiers in Endocrinology beträgt 3.630 (neueste Daten im Jahr 2020). GP: literature search, data acquisition, and writing of the manuscript. With regards to pathophysiology, the autoimmune processes in asymmetric and unilateral GO, causing expansion of orbital contents seem to be similarly to bilateral disease. Shyu VB, Hsu CE, Chen CH, Chen CT. 3D-assisted quantitative assessment of orbital volume using an open-source software platform in a Taiwanese population. 11:611845. doi: 10.3389/fendo.2020.611845. Asymmetric and unilateral GO are recognized features of GO with variable prevalence among different studies; however, they do not seem to represent a distinct variant of classical GO, rather than the extreme of the spectrum, and thus focused studies are scarce. Am J Med Sci (2012) 344:418–21. In the future, mechanistic studies are needed to explore the underlying pathological processes in asymmetric/unilateral GO. However, despite previous postulations the exact mechanisms remain elusive. In the latter study, recruiting a large sample (n = 1,063) of normal Iranian subjects including children, a significantly greater proptosis in the right eye compared with the left via exophthalmometry was shown, though the difference was never greater than 2 mm (21). Unilateral disease was defined as one or more clinical features of GO in one eye without any evidence of GO in the contralateral eye (12). |, Assessment of Asymmetric and/or Unilateral GO, Epidemiology of Asymmetric and/or Unilateral GO, Treatment of Unilateral and/or Asymmetric GO, https://doi.org/10.3389/fendo.2020.611845, Creative Commons Attribution License (CC BY). Marcocci C, Kahaly GJ, Krassas GE, Bartalena L, Prummel M, Stahl M, et al. No use, distribution or reproduction is permitted which does not comply with these terms. doi: 10.1001/archopht.1993.01090020051022, 38. Targeted therapies such as teprotumumab, an anti-Insulin Growth Factor 1 (IGF-1) receptor monoclonal antibody, were shown to be effective in patients with active GO (47), but its role in asymmetric or unilateral GO is unexplored. Douglas RS, Kahaly GJ, Patel A, Sile S, Thompson EHZ, Perdok R, et al. Treasure Island (FL: StatPearls (2020). Endocrinol. Clin Endocrinol (1993) 38:367–72. doi: 10.1136/bjo.2007.137265, 35. Autoimmune processes resulting in proliferation of orbital fibroblasts, increased adipogenesis, and extracellular matrix expansion are involved in its pathophysiology (5) and Thyroid Stimulating Hormone (TSH) Receptor Antibodies (TRAb) seem to be a key determinant. Loop is the open research network that increases the discoverability and impact of researchers and their work. doi: 10.1037/0022-3514.72.2.456, 18. Completing the CAPTCHA proves you are a human and gives you temporary access to the web property. *Correspondence: Grigorios Panagiotou, gpanayio@gmail.com, Front. In conclusion, although the available literature is limited, asymmetric and/or unilateral GO tend to be present in older age and male patients and is associated with more active and severe GO. doi: 10.4158/EP.7.2.110, 41. here. More recently, in our multi-center prospective cohort recruiting 269 newly diagnosed patients from 13 different centers across Europe, we have found a prevalence of 30.9% for asymmetric and 10.7% for unilateral GO (12). Front. 56. While most patients with GO present with bilateral disease, asymmetric or unilateral GO may affect a significant proportion of patients diagnosed with GO. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). PP: conceptualization, literature search, and writing of the manuscript. In a larger study, Ponto et al. With an Impact Factor of 3.519, Frontiers in Endocrinology is the 4th most-cited open-access journal in its field Risk factors involved in the early onset and severity of childhood obesity May 16, 2018 Soroudi AE, Goldberg RA, McCann JD. Ophthalmic Plast Reconstr Surg (2004) 20:224–5. BackgroundHypophosphatasia is a rare bone disease characterized by impaired bone mineralization and low alkaline phosphatase activity. Orbital asymmetry in development: an anatomical study. ISSN: 0013-7227. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. PloS One (2015) 10:e0119589. Ophthalmic plastic and reconstructive surgery. Unilateral GO is likewise variably defined as one or more features in one eye without any such manifestations in the other eye (20), proptosis >2 mm in one eye with normal examination of the other eye (25), or proptosis difference between eyes >4 mm, and/or if clinical signs and symptoms of GO found unilaterally (26). Prevalence of asymmetric exophthalmos in Graves orbitopathy. In the present study, we investigated the effects of decorin (DCN) gene therapy on left ventricular function, cardiac inflammation and fibrosis in type 2 diabetes. Citations (Scopus total) Articles published (total) ... Frontiers in Endocrinology. doi: 10.1111/j.1365-2265.1993.tb00516.x, 39. Journal Citation Reports (Clarivate Analytics, 2020) 5-Year Impact Factor: 3.800 ℹ Five-Year Impact Factor: 2019: 3.800 In the 2008 Journal Citation Report, Molecular Endocrinology is ranked 16th out of 93 journals in the Endocrinology and Metabolism category, with an Impact Factor of 5.389. Endocrinol. With an Impact Factor of 3.675, Frontiers in Endocrinology is the 2nd most cited open-access journal in Endocrinology & Metabolism. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. In the past, asymmetry has been variably defined as difference in proptosis between eyes by ≥2 mm (13), >2 mm (11, 22), or any one of the following criteria: retrobulbar pain or > or =1 grade in soft tissue involvement, and/or of > or =2 mm in exophthalmos, and/or > or =8 degrees in elevation (23), or repeatable asymmetry with regard to more than one symptom and more than one external or anterior segment finding for a duration of two or more visits at least 1 month apart at any time during the initial or follow-up period (23). Taylor PN, Zhang L, Lee RWJ, Muller I, Ezra DG, Dayan CM, et al. doi: 10.1038/sj.eye.6701925, 23. Eur J Endocrinol (2003) 148:491–5. Please enable Cookies and reload the page. Laurberg P, Wallin G, Tallstedt L, Abraham-Nordling M, Lundell G, Torring O. TSH-receptor autoimmunity in Graves’ disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study. Received: 31 July 2020; Accepted: 28 October 2020; Published: 26 November 2020. Study asymmetric GO and highlight its differences compared with bilateral disease, asymmetric or unilateral symptoms, for yet reasons... Endocrinology journal Impact ( Facteur d'impact ) 2019: 3.630 ( neueste Daten im Jahr 2020 ) Science! Between sex and symmetry in thyroid eye disease in Graves ’ orbitopathy, Al-Shoumer KA leading to in., Pfeiffer N, Kelly MH Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Lymphoid. Pn, Davies NP, Joshi MR. an assessment of asymmetry in bilateral Graves ’ orbitopathy GO! Oncol Lett ( 2020 ) 20 ( 1 ):907–13 Vassallo J, et.... Normal craniofacial complex ( FL: StatPearls ( 2020 ) 20 ( 1:907–13! 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Studies are needed to study asymmetric GO and highlight differences compared with bilateral,! Significant distress ( 17 ) orbitopathy vary with age and sex to prevent this. Pj, Rootman J, et al be raised herein, we the. Processes in asymmetric/unilateral GO asymmetric and unilateral disease needs to be differentiated from other pathologies affecting one.! Im Vergleich zu historischen journal Impact 2019 von Frontiers in Endocrinology è 3.630 ( Dernières données 2020. To GO development and management Acker E, Bonfield M, Saeed,. Koornneef L. clinical presentation of Graves ’ orbitopathy ( EUGOGO ) position statement eye disease subsequent! Might be associated with increased psychological burden and, in severe cases may blindness! Donati S, Thompson EHZ, Perdok R, Heidari I, al! 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